Midfielder Dele Alli has been named in Tottenham's squad for their Champions League quarter-final second leg but will be assessed before Spurs decide if he will play against Manchester City.
Alli broke his hand in last week's first leg but has returned to training.
City midfielder Fernandinho has trained after missing Sunday's win over Crystal Palace with a muscle problem.
Sergio Aguero was withdrawn late on at Palace but is fit, although Oleksandr Zinchenko (hamstring) is a doubt.
Spurs forward Erik Lamela, who has not played since the last-16 second leg against Borussia Dortmund on 5 March because of a hamstring injury, has also trained and like Alli will be assessed after Tuesday's training session.
On Alli, manager Mauricio Pochettino said: "We are going to have the last training session today and then need to decide if it's possible he can be in the starting XI or on the bench."
Serge Aurier (hamstring), Eric Dier (hip flexor) and Harry Winks (groin) are all out, as is striker Harry Kane after he suffered an ankle injury in the first leg.
Tottenham take a 1-0 lead to the Etihad Stadium after Son Heung-min's goal in the first leg last Tuesday.
Spurs are aiming to reach the Champions League semi-final for the first time but Pochettino says City are still favourites to win the Champions League, despite their deficit from the first leg.
"Manchester City for me is one of the best teams in the world and a clear favourite to win the Premier League and the Champions League," he said.
"For us to beat them in the first leg was an amazing result but we know very well the tie is still open and tomorrow is going to be very, very tough.
"But we have the belief that we are going to fight. Tomorrow is going to be an amazing challenge and fight. I am so motivated and excited."
City manager Pep Guardiola has challenged the Man City fans to create an atmosphere on Wednesday similar to the one when they beat Liverpool 2-1 in the league in January.
"I'm really curious how are fans are going to react," he said.
"[An atmosphere like] the Liverpool game will be enough for me - a little bit better. I want to see if they [the fans] want to get to the semi-finals.
"Do it for the guys - the last 20 months, they are so proud with what they have done but they are human beings.
"They will have bad moments in the games and at that moment we need our supporters.
"At this stage, without supporters, we cannot go through. I'm expecting."
Here is the lineup below
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